Gainers Quoin Pharmaceuticals, Ltd. (NASDAQ: QNRX ) shares surged 360.5% to settle at $19.80 on Wednesday on above-average volume. ECMOHO Limited (NASDAQ: MOHO ) jumped 146.1% to settle at $0.4085 on above-average volume. Helius Medical Technologies, Inc. (NASDAQ: HSDT ) shares climbed 145.3% to close at $1.58 on Wednesday after dropping 13% on Tuesday. Kaspien Holdings Inc. (NASDAQ: KSPN ) jumped 140.3% to close at $6.20. Enveric Biosciences, Inc. (NASDAQ: ENVB ) gained 106% to settle at $13.10. Enveric Biosciences recently announced an $8 million registered direct offering and private placement. Heart Test Laboratories, Inc. (NASDAQ: HSCS ) jumped 89.6% to close at $3.28. Poseida Therapeutics, Inc. (NASDAQ: PSTX ) shares surged 85.6% to close at $4.51 as the company entered into a strategic collaboration and license agreement with Roche Holdings AG, focused on developing allogeneic CAR-T therapies directed to hematologic malignancies. Eargo, Inc. (NASDAQ: EAR ) shares gained 75.6% to settle at $1.23.
At the close of the New York Stock Exchange, the Dow Jones was up 0.27%, the S&P 500 was down 0.07% and the NASDAQ Composite was down 0.03%. McDonald''s Corporation was the leading gainer among the components of the Dow Jones in today''s trading, up 4.91 points or 2.02% to close at 247.74. Quotes of Microsoft Corporation rose by 3.78 points (1.47%), closing trading at 260.26. UnitedHealth Group Incorporated rose 7.27 points or 1.43% to close at 515.71. The biggest losers were Caterpillar Inc, which shed 3.96 points or 2.11% to end the session at 183.48. Chevron Corp was up 1.97% or 2.96 points to close at 146.98 while American Express Company was down 1.91% or 2.72 points to close at 139. 47. Among the S&P 500 index components gainers in today''s trading were General Mills Inc, which rose 6.35% to 74.72, ABIOMED Inc, which gained 2.97% to close at 256.49, and shares of Monster Beverage Corp, which rose 2.80% to end the session at 93.35. The biggest losers were shares of Carnival Corporation, which shed 14.13% to close at 8.87.